Cisplatin in vivo action on lipid content in nuclear matrix from rat brain cells

E. S. GEVORGYAN; ZH. V. YAVROYAN; N. R. HAKOBYAN; A. G. HOVHANNISYAN; E. G. SARGSYAN

E. S. GEVORGYAN Yerevan State University, Department of Biophysics
ZH. V. YAVROYAN Yerevan State University, Department of Biophysics
N. R. HAKOBYAN Yerevan State University, Department of Biophysics
A. G. HOVHANNISYAN Yerevan State University, Department of Biophysics
E. G. SARGSYAN Yerevan State University, Department of Biophysics

Keywords: Cisplatin – brain – nuclear matrix – phospholipids – neutral lipids

Abstract

The content of total phospholipids and neutral lipids as well as their individual fractions in nuclear matrix preparations from rat brain cells after in vivo action of the antitumor drug cisplatin was investigated. It was revealed that cisplatin administration reduced the total quantity of nuclear matrix phospholipids and neutral lipids by about 28% and 25% respectively. The diminution of total lipids quantity was accompanied by alterations in quantities of individual fractions of phospholipids and neutral lipids. These data demonstrate the high sensitivity of lipids metabolism in nuclear matrix preparations to antitumor drug cisplatin action. It was supposed that the cisplatin antitumor action can be performed also via quantitative changes of internuclear lipids, which are able to regulate the principal functions of cell nuclei.

Author Biographies

E. S. GEVORGYAN, Yerevan State University, Department of Biophysics

Է. Ս. Գևորգյան

gevorgyan_emil@yahoo.com

ZH. V. YAVROYAN, Yerevan State University, Department of Biophysics

Ժ. Վ. Յավրոյան

N. R. HAKOBYAN, Yerevan State University, Department of Biophysics

Ն. Ռ. Հակոբյան

A. G. HOVHANNISYAN, Yerevan State University, Department of Biophysics

Ա. Գ. Հովհաննիսյան

E. G. SARGSYAN, Yerevan State University, Department of Biophysics

Է. Գ. Սարգսյան