In vivo action of cisplatin on lipid content in nuclear membranes from rat brain cells

E. S. GEVORGYAN; ZH. V. YAVROYAN; N. R. HAKOBYAN; A. G. HOVHANNISYAN; E. G. SARGSYAN

E. S. GEVORGYAN Yerevan State University, Department of Biophysics
ZH. V. YAVROYAN Yerevan State University, Department of Biophysics
N. R. HAKOBYAN Yerevan State University, Department of Biophysics
A. G. HOVHANNISYAN Yerevan State University, Department of Biophysics
E. G. SARGSYAN Yerevan State University, Department of Biophysics

Keywords: Cisplatin – nuclear membrane – phospholipids – neutral lipids

Abstract

The in vivo action of antitumor drug cisplatin on content of phospholipids and neutral lipids in nuclear membrane fraction from rat brain cells has been investigated. It was shown, that the drug action leads to decrease in total phospholipids and neutral lipids content by about 27.5% and 25% respectively. In spite of these significant changes of total lipids the alterations in relative percentage content of individual phospholipids as well as neutral lipids in nuclear membrane preparations were negligible. These results indicate that cisplatin excites universal changes in lipid metabolism in nuclear membranes appreciably reducing the absolute quantities almost of all individual phospholipid and neutral lipid fractions available in nuclear membranes preparations. The significance of these quantitative changes in development of cisplatin antitumor effects was discussed.

Author Biographies

E. S. GEVORGYAN, Yerevan State University, Department of Biophysics

Է. Ս. Գևորգյան

gevorgyan_emil@yahoo.com

ZH. V. YAVROYAN, Yerevan State University, Department of Biophysics

Ժ. Վ. Յավրոյան

N. R. HAKOBYAN, Yerevan State University, Department of Biophysics

Ն. Ռ. Հակոբյան

A. G. HOVHANNISYAN, Yerevan State University, Department of Biophysics

Ա. Գ. Հովհաննիսյան

E. G. SARGSYAN, Yerevan State University, Department of Biophysics

Է. Գ. Սարգսյան