Effect of mutations and phosphorylation on pyrin structure

H. K. SAHAKYAN; G. G. ARAKELOV; K. B. NAZARYAN

H. K. SAHAKYAN Institute of Molecular Biology NAS RA
G. G. ARAKELOV Institute of Molecular Biology NAS RA, Laboratory of computational modeling of biological processes Russian-Armenian (Slavonic) university
K. B. NAZARYAN Institute of Molecular Biology NAS RA, Laboratory of computational modeling of biological processes Russian-Armenian (Slavonic) university

Keywords: FMF – pyrin – computer modeling

Abstract

Computer models of mutant and phosphorylated forms of pirin have been generated. A comparison of the structures showed differences in pyrin structure which can affect complex formation of pyrin with other effectors.

Author Biographies

H. K. SAHAKYAN, Institute of Molecular Biology NAS RA

Հ. Կ. Սահակյան

sahakyanhk@gmail.com

G. G. ARAKELOV, Institute of Molecular Biology NAS RA, Laboratory of computational modeling of biological processes Russian-Armenian (Slavonic) university

Գ. Գ. Առաքելով

K. B. NAZARYAN, Institute of Molecular Biology NAS RA, Laboratory of computational modeling of biological processes Russian-Armenian (Slavonic) university

Կ. Բ. Նազարյան
karen.nazaryan@gmail.com