Analysis of somatic mutation enrichment in gene expression landscapes for cancer cell lines

Abstract

This study is aimed at assessing the association between somatic mutations and gene expression in NCI-60 cancer cell lines using publicly available dataset and bioinformatics approaches. The study results demonstrate that the deregulation in gene expression profiles in cancer only partly can be attributed to the presence of somatic mutations, which implies the importance of assessment of epigenetic mechanisms of regulation and multi-omics data integration for cancer systems biology.