Cisplatin in vivo action on lipid content in chromatin from rat kidney cells

E. S. GEVORGYAN; ZH. V. YAVROYAN; A. G. HOVHANNISYAN; N. R. HAKOBYAN; E. G. SARGSYAN

E. S. GEVORGYAN Yerevan State University, Department of Biophysics
ZH. V. YAVROYAN Yerevan State University, Department of Biophysics
A. G. HOVHANNISYAN Yerevan State University, Department of Biophysics
N. R. HAKOBYAN Yerevan State University, Department of Biophysics
E. G. SARGSYAN Yerevan State University, Department of Biophysics

Keywords: Cisplatin – kidney – chromatin – phospholipids – neutral lipids

Abstract

The content of total phospholipids and neutral lipids as well as of their individual fractions in chromatin preparations from rat kidney cells after in vivo action of the antitumor drug cisplatin was investigated. It was established that cisplatin treatment reduced the total quantity of chromatin phospholipids and neutral lipids by about 25% and 23% correspondingly. The diminution of total lipids quantity was accompanied by alterations in quantities of individual fractions of phospholipids and neutral lipids. These data demonstrate the high sensitivity of chromatin lipids metabolism to antitumor drug cisplatin action. It was supposed that the cisplatin antitumor action can be realized via quantitative changes of chromatin lipids, which are able to regulate the principal functions of cell nuclei.

Author Biographies

E. S. GEVORGYAN, Yerevan State University, Department of Biophysics

Է.Ս.Գևորգյան

gevorgyan_emil@yahoo.com

ZH. V. YAVROYAN, Yerevan State University, Department of Biophysics

Ժ.Վ. Յավրոյան

A. G. HOVHANNISYAN, Yerevan State University, Department of Biophysics

Ա.Գ. Հովհաննիսյան

N. R. HAKOBYAN, Yerevan State University, Department of Biophysics

Ն.Ռ.Հակոբյան

E. G. SARGSYAN, Yerevan State University, Department of Biophysics

Է.Գ. Սարգսյան