The relationship between arginase activity and change of polyamines quantity in human blood serum during breast cancer

N. V. AVTANDILYAN; S. A. KARAPETYAN; K. A. ALEKSANYAN

N. V. AVTANDILYAN Yerevan State University, Department of Biochemistry
S. A. KARAPETYAN Yerevan State University, Department of Biochemistry
K. A. ALEKSANYAN Clinical-biochemical laboratory at National Center of Oncology aft. V.A.Fanarjyan

Keywords: Arginase – polyamine – breast cancer – diagnosis and treatment

Abstract

Cancer cells may differ from their normal counterparts in the activities of certain enzymes. That difference may act as a useful biological marker of malignancy in particular tumors. Arginase (EC 3.5.3.1) hydrolyses L-arginine into urea and L-ornithine (precursor for polyamines). The enzyme activity as a test for cancer diagnosis and treatment is suggested. The main goal of the study is not only to reveal a new tumor marker, but also to clarify new relationship mechanisms between Arginase activity and change of polyamines quantity in healthy and cancer cells, which will allow influencing metabolic different processes of cancer cells.

Author Biographies

N. V. AVTANDILYAN, Yerevan State University, Department of Biochemistry

Ն. Վ. Ավթանդիլյան

nv.avtandilyan@ysu.am

S. A. KARAPETYAN, Yerevan State University, Department of Biochemistry

Ս. Ա. Կարապետյան

K. A. ALEKSANYAN, Clinical-biochemical laboratory at National Center of Oncology aft. V.A.Fanarjyan

Ք. Ա. Ալեքսանյան