Study of L-tyrosine and pyridinecarboxaldehydes derived schiff base copper complexes as potential radioprotective agents
Keywords:
Ionizing radiation – copper – complex – L-Tyrosine – pyridinecarboxaldehyde – radioprotection – antioxidant
Abstract
Radioprotective properties of copper complexes with Schiff Bases derived from L-Tyrosine aromatic amino acid and 2-, 3-, or 4-pyridinecarboxaldehydes (Cu.2-Tyr, Cu.3-Tyr, and Cu.4-Tyr) were investigated in rats subcutaneously or orally treated with metallocomplexes at 10 or 40 mg/kg doses 1 or 24 hours before Xray irradiation at 650 R that composes LD50/30 for untreated control irradiated animals. According to the study results, at all the applied schemes of animals preventive treatment Cu.2-Tyr failed to manifest radioprotection. However, Cu.3-Tyr and Cu.4-Tyr demonstrated expressed radioprotective activity that might be mainly related to their respective support of endogenous non-enzymatic antioxidant defence system of the organism.
