Changes in sphingomyelin and phosphatidylcholine content in rat liver nuclear structures during the in vivo action of cisplatin.

E. S. GEVORGYAN; ZH. V. YAVROYAN; N. R. HAKOBYAN; A. G. HOVHANNISYAN; E. G. SARGSYAN

E. S. GEVORGYAN Yerevan State University, Department of Biophysics
ZH. V. YAVROYAN Yerevan State University, Department of Biophysics
N. R. HAKOBYAN Yerevan State University, Department of Biophysics
A. G. HOVHANNISYAN Yerevan State University, Department of Biophysics
E. G. SARGSYAN Yerevan State University, Department of Biophysics

Keywords: Cisplatin – sphingomyelin – phosphatidylcholine – nuclear membrane – nuclear matrix – chromatin

Abstract

The content of sphingomyelin and phosphatidylcholine in rat liver nuclear membranes, nuclear matrix and chromatin was studied during the in vivo action of cisplatin. It was shown that the action of antitumor agent lead to decrease of content of both sphingolipids in all studied nuclear structures. At the same time the sphingomyelin: phospatidylcholine ratio was also significantly (nearly twice)decreased.

Author Biographies

E. S. GEVORGYAN, Yerevan State University, Department of Biophysics

Է. Ս.Գևորգյան

gevorgyan_emil@yahoo.com

ZH. V. YAVROYAN, Yerevan State University, Department of Biophysics

Յ. Վ. Յավրոյան

N. R. HAKOBYAN, Yerevan State University, Department of Biophysics

Ն. Ռ. Հակոբյան

A. G. HOVHANNISYAN, Yerevan State University, Department of Biophysics

Ա. Գ. Հովհաննիսյան

E. G. SARGSYAN, Yerevan State University, Department of Biophysics

Է. Գ. Սարգսյան