The influence of glutamine and ethanolamine-O-sulphate on neuroactive amino acids content in the rat organs in norm and with experimental streptozotocine diabetes

Abstract

The research studies the separate and combined action of inhibitor of GABA-T ethanolamine-O-sulfate (EOS) and glutamate and GABA precursor glutamine on glutamine family amino acid content in the brain and liver of rats. The study demonstrates a higher efficiency of combined administration of those compounds at GABA level in brain and liver. The combined administration of those compounds produces a protective effect on the amino acids in the organs of rats with experimental streptozotocine diabetes, more specifically, in the brain and the pancreas. The pancreas of rats maintains concentrations of neuroactive amino acids the compared with brain. Given the role of GABA in the regulation and secretion of insulin, the combined use of glutamine and EOS can be substantial in the first type diabetes.