Age-dependent difference in thymocyte poly (ADP-ribose) polymerase 1 inhibition after the in vivo treatment of rats with cisplatin

I. G. ARTSRUNI; A. L. ASATRYAN; K. S. MATINYAN; E. S. GEVORGYAN

I. G. ARTSRUNI Yerevan State University, Department of Biophysics
A. L. ASATRYAN Yerevan State University, Department of Biophysics
K. S. MATINYAN Yerevan State University, Department of Biophysics
E. S. GEVORGYAN Yerevan State University, Department of Biophysics

Համառոտագիր

Immunosupression is the most common toxic side-effect elicited by treatment with cisplatin. To improve cytotoxic effect of cisplatin, nowadays poly(ADP-ribose)polymerase 1 (PARP 1) inhibitors are employed in cancer treatment. Driven with the knowledge that agerelated thymic involution is a part of immune system degeneration, the enzyme inhibition in thymocyte nuclei of different age rats treated with cisplatin is investigated in the present study. Presented data show that treatment of intact rats with cisplatin had no appreciable effect on pubertal age (4 week old) male thymocyte, whilst elicited elevation of PARP 1 activity by 40% in female counterparts. Administration of cisplatin to young adult females (10 week old) enhanced PARP-1 activity nearly by 60%. It was revealed that administration of cisplatin to rats displayed age-dependent modulation in PARP 1 inhibition by benzamide and ATP in thymocyte.

Author Biographies

I. G. ARTSRUNI, Yerevan State University, Department of Biophysics

Ի.Գ. Արծրունի

A. L. ASATRYAN, Yerevan State University, Department of Biophysics

Ա.Լ. Ասատրյան

K. S. MATINYAN, Yerevan State University, Department of Biophysics

Կ.Ս. Մատինյան

E. S. GEVORGYAN, Yerevan State University, Department of Biophysics

Է.Ս. Գևորգյան