The role of thyroid gland activity markers under subclinical hypothyreoidism in rats

Abstract

The aim of this study was to investigate the features of thyroid stimulating hormone and thyroid hormones concentrations in the blood serum of the rats with subclinical hypothyroidism before and after injection of ultra-low dose of choline ether N-(2-metoxybenzoyl)-O-isopropyl-α, β-dehydrothyrozine. The studies have shown that a sharp increase of thyroid stimulating hormone level and a drop of thyroid hormones level in the blood serum occur at 10 month-old rats with
subclinical hypothyroidism. The action of ultra-low dose of choline ether N-(2-metoxybenzoyl)-Oisopropyl-α, β-dehydrothyrozine in the blood serum of hypothyroid rats brings to a decrease in the concentration of thyroid stimulating hormone, thyroid hormones level rises and reaches their values at intact animals.