Changes in the F0F1-ATPase activity of irradiated Lactobacillus acidophilus in the presence of ceftazidime at low pH.

D. R. SOGHOMONYAN; V. P. KALANTARYAN; A. H. TRCHOUNIAN

D. R. SOGHOMONYAN Department of Microbiology, Plants and Microbes Biotechnology, Yerevan State University
V. P. KALANTARYAN Department of Microwave Radiophysics and Telecommunication, Yerevan State University
A. H. TRCHOUNIAN Department of Microbiology, Plants and Microbes Biotechnology, Yerevan State University

Keywords: L. acidophilus – low pH – ATPase activity

Abstract

The aim of this study was the investigation of the effects of low intensity electromagnetic irradiation (EMI) at the frequencies of 51.8 and 53 GHz and of antibiotic ceftazidime on the N,N'- dicyclohexilcarbodiimide (DCCD) inhibited ATPase activity of membrane vesicles of lactic acid bacteria Lactobacillus acidophilus grown at low pH (pH 4.0 or 6.5) and assayed at the same pH. It was shown that both frequencies EMI stimulated ATPase activity of L. acidophilus grown at pH 4.0, but EMI combined with ceftazidime and DCCD decreased ATPase activity at pH 4.0 and pH 6.5. It was suggested that the F0F1-ATPase might be a target for EMI even at low pH.

Author Biographies

D. R. SOGHOMONYAN, Department of Microbiology, Plants and Microbes Biotechnology, Yerevan State University

Դ. Ռ. Սողոմոնյան

d.soghomonyan@ysu.am

V. P. KALANTARYAN, Department of Microwave Radiophysics and Telecommunication, Yerevan State University

Վ. Պ. Քալանթարյան

A. H. TRCHOUNIAN, Department of Microbiology, Plants and Microbes Biotechnology, Yerevan State University

Ա. Հ. Թռչունյան