Risk of FMF development among heterozygous patients in Armenian population Biology

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Published: Dec 15, 2016
Keywords:
familial Mediterranean fever, MEFV gene mutations, pseudodominant inheritance.

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H. S. Hayrapetyan
Center of Medical Genetics and Primary Health Care; Yerevan State Medical University after Mkhitar Heratsi
T. F. Sarkisian
Center of Medical Genetics and Primary Health Care
S. А. Atoyan
Center of Medical Genetics and Primary Health Care; Yerevan State Medical University after Mkhitar Heratsi

Abstract

The aim of this study is the investigation of one mutation carriers of MEFV gene among Armenian population. We designed and established the genetic register for proper collection of patients’ data including their ethnicity, clinical and laboratory data, as well as family cases. According to the results the frequency of FMF inheritance with only one mutation of MEFV gene among Armenian population is about 17.5% and by autosomal-recessive mode (homozygous or compound-heterozygous) is 82.5%.

Article Details

Issue
Vol 241 No 3 (2016): Volume 241 No 3
Section
Articles
Author Biographies

H. S. Hayrapetyan, Center of Medical Genetics and Primary Health Care; Yerevan State Medical University after Mkhitar Heratsi

H. S. Hayrapetyan

Center of Medical Genetics and Primary Health Care, Armenia

Yerevan State Medical University after Mkhitar Heratsi, Armenia

T. F. Sarkisian, Center of Medical Genetics and Primary Health Care

T. F. Sarkisian

Center of Medical Genetics and Primary Health Care, Armenia
E-mail: tamsar@sci.am

S. А. Atoyan, Center of Medical Genetics and Primary Health Care; Yerevan State Medical University after Mkhitar Heratsi

S. A. Atoyan

Center of Medical Genetics and Primary Health Care, Armenia
 Yerevan State Medical University after Mkhitar Heratsi, Armenia