Effects of d-amphetamine on regional activity of arginase isoforms in rat corticolimbic brain Biology

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Published: Dec 15, 2016
Keywords:
arginase, bipolar disorder, corticolimbic brain, cytoplasm, nitric oxide, d-amphetamine, mitochondria.

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H. А. Movsesyan
H. Bunyatyan Institute of Biochemistry NAS RA
N. Kh. Alchujyan
H. Bunyatyan Institute of Biochemistry NAS RA
А. А. Aghababova
H. Bunyatyan Institute of Biochemistry NAS RA
N. H. Movsesyan
H. Bunyatyan Institute of Biochemistry NAS RA
M. R. Hovhannisyan
H. Bunyatyan Institute of Biochemistry NAS RA
А. M. Hakobyan
H. Bunyatyan Institute of Biochemistry NAS RA
I. V. Hovsepyan
Yerevan Medical State University after Mkhitar Heratsi
H. F. Khachatryan
H. Bunyatyan Institute of Biochemistry NAS RA
G. А. Kevorkian
H. Bunyatyan Institute of Biochemistry NAS RA

Abstract

 In the present work cytoplasmic and mitochondrial arginase isoforms (ARG1 and ARG2 respectively) are studied in the rat corticolimbic brain regions in amphetamine induced bipolar disorder (BD). Escalating non-neurotoxic doses of d-amphetamine sulfate (AMPH) injected to rats over 24 days induce changes in behavior mimicking BD accompanied by alterations in resident microbiota with manifestation of pathogenic bacteria. Both ARG1 and ARG2 are stimulated in the brain corticolimbic regions involved in the formation of emotions, learning and memory. Simultaneously, NO stable metabolite levels are diminished or not changed in the cytoplasm and mitochondria of the brain regions studied in AMPH-treated rats. It is suggested that arginase isoforms may contribute the NOsynthase inhibition and prevention of detrimental effects of the reactive nitrogen species overproduced in BD.

Article Details

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Vol 241 No 3 (2016): Volume 241 No 3
Section
Articles
Author Biographies

H. А. Movsesyan, H. Bunyatyan Institute of Biochemistry NAS RA

H. A. Movsesyan

H. Bunyatyan Institute of Biochemistry NAS RA

N. Kh. Alchujyan, H. Bunyatyan Institute of Biochemistry NAS RA

N. Kh. Alchujyan

H. Bunyatyan Institute of Biochemistry NAS RA

А. А. Aghababova, H. Bunyatyan Institute of Biochemistry NAS RA

A. A. Aghababova

H. Bunyatyan Institute of Biochemistry NAS RA

N. H. Movsesyan, H. Bunyatyan Institute of Biochemistry NAS RA

N. H. Movsesyan

H. Bunyatyan Institute of Biochemistry NAS RA

M. R. Hovhannisyan, H. Bunyatyan Institute of Biochemistry NAS RA

M. R. Hovhannisyan

H. Bunyatyan Institute of Biochemistry NAS RA

E-mail: margarita.hovhannisyan@mail.ru

А. M. Hakobyan, H. Bunyatyan Institute of Biochemistry NAS RA

A. M. Hakobyan

H. Bunyatyan Institute of Biochemistry NAS RA

I. V. Hovsepyan, Yerevan Medical State University after Mkhitar Heratsi

I. V. Hovsepyan

Yerevan Medical State University after Mkhitar Heratsi, Armenia

H. F. Khachatryan, H. Bunyatyan Institute of Biochemistry NAS RA

H. F. Khachatryan

H. Bunyatyan Institute of Biochemistry NAS RA

G. А. Kevorkian, H. Bunyatyan Institute of Biochemistry NAS RA

G. A. Kevorkian

H. Bunyatyan Institute of Biochemistry NAS RA;
Chair of Department of Pathological Biochemistry and Radioisotope Methods