Synthesis of new 3-cyanopyridine-2(1H)-ones with unsaturated substituents at C-4 Chemistry

Abstract

3-Cyanopyridine-2(1H)-ones containing unsaturated substituents at the position C-4 and various substituents at N-1 of the ring have been synthesized as new potential bioactive compounds by interaction of ethyl ylidene cyanoacetate with dimethylformamide dimethyl acetal, and simultaneous reamination-cyclization of obtained derivatives with amines to targeted 3-cyanopyridine-2(1H)-ones.