Adenosine deaminase isoforms in synovial fluid at rheumatoid arthritis Biology

Abstract

The level of adenosine deaminase (ADA) activity in synovial fluids of patients with inflammatory arthritis (IA) and non-inflammatory joint diseases differ significantly. In this work from synovial fluids with different levels of the ADA activity, low- and high-molecular isoforms were separated. The increasing of low-/high- molecular ratio upon increasing the total ADA activity was manifested. It was supposed that the increase of total ADA activity at inflammation takes place, because of the release of intracellular, low-molecular ADA. To prevent the anti-inflammatory agent, adenosine, against metabolizing by the enzyme, its inhibition might be considered as a new approach to the IA treatment.